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Observe Closely (1)pentobarbital will decrease the level or outcome of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to some reduce in fentanyl plasma concentrations, deficiency of efficacy or, probably, growth of a